Table 2.
Demographic, histopathological, and MR imaging and spectroscopy results in the two subgroups.
| Characteristic | Subgroup | Statistical Analysis | ||
|---|---|---|---|---|
| 1 | 2 | Statistic | p | |
| Demographics | ||||
| Age (y) | 42.3 ± 14.2 | 41.8 ± 13.2 | 0.027 | 0.98 |
| Sex (male/female) | 8/11 | 17/10 | 1.96 | 0.16 |
| Histopathology | ||||
| Low grade (II) | 7 (37%) | 13 (48%) | 0.58 | 0.45 |
| High grade (III + IV) | 12 (63%) | 14 (52%) | - | - |
| IDHmut (with/without) | 10/9 | 11/16 | 0.64 | 0.44 |
| MGMTmet (with/without) | 12/7 | 10/17 | 3.05 | 0.081 |
| ATRX loss (with/without) | 9/10 | 12/15 | 0.038 | 0.85 |
| Ki-67 proliferation index | 0.15 ± 0.12 | 0.20 ± 0.16 | −1.07 | 0.29 |
| MR imaging | ||||
| Connectivity | 2675 ± 1098 | 30432 ± 22707 | −5.23 | p = 0.000016 * |
| FA | 0.34 ± 0.116 | 0.30 ± 0.108 | 1.15 | 0.26 |
| rCBV | 2.31 ± 0.95 | 1.73 ± 0.48 | −3.11 | 0.002 * |
| rADC | 1.32 ± 0.25 | 1.21 ± 0.27 | −1.58 | 0.12 |
| MR spectroscopy | ||||
| Cho/Cr | 0.52 ± 0.26 | 0.74 ± 0.57 | −1.49 | 0.14 |
| NAA/Cr | 0.96 ± 0.62 | 0.77 ± 0.41 | −1.43 | 0.14 |
| Cho/NAA | 1.07 ± 0.54 | 1.34 ± 0.42 | −1.49 | 0.13 |
| Lip/Cr | 0.32 ± 0.22 | 0.060 ± 0.051 | −2.71 | 0.006 * |
| Lac/Cr | 0.62 ± 0.85 | 0.45 ± 0.32 | −0.72 | 0.47 |
Results are mean ± SD or numbers in two categories (x/y). Abbreviations: IDHmut, isocitrate dehydrogenase mutation; MGMTmet, O6-methylguanine-methyltransferase promoter methylation; ATRX loss: alpha thalassemia/mental retardation syndrome X-linked loss; FA, fractional anisotropy; rCBV, relative cerebral blood volume; NAA, N-acetylaspartate; Cr, creatine; Cho, choline; Lac, lactate; Lip, lipid; and rADC, relative apparent diffusion coefficient. * p is less than 0.05.