Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 30;12(13):2248. doi: 10.3390/nano12132248

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

(A) In vivo retention of PLGA NPs and PLGA-HA NPs loaded with NIR dye for 15 days after IA injection in the right knee. The pictures depict a representative mouse for each NP treatment group at 3 different time points. From left to right, after 1, 7, and 15 days of NPs intra-articular injection. (B) The in vivo retention was measured as the average radiation intensity of each NP treatment over time, at 6 time points, in the OA knee. The control curve represents free dye injected intra-articularly and was used as a baseline comparison with the NPs. In vivo retention of PLGA NPs and PLGA-HA NPs loaded with gold and co-loaded with NIR dye followed for 15 days after IA injection in the right knee. (C) µCT scan of knee joints showing a 3D view of the bone surface. From left to right, representative pictures of knee treated with PLGA NPs, PLGA-HA NPs, and healthy knee (negative control) (n = 3).