Table 4.

Relationship of Treatment-Associated Side Effects to Potential Factors of Influence ^*

	Patients With Nausea and/or Emesis	Patients With Neither Nausea nor Emesis	p value
Factor, median (IQR)
Age, yr	9.0 (5.0 to 13.0)	9.5 (4.1 to 14.8)	0.75*
Dose of INF, μg/kg	1.5 (1.4 to 1.5)	1.5 (1.5 to 1.6)	0.90*
NO2 total application time, min	10.0 (0.8 to 19.3)	10.0 (2 to 18)	0.71*
Time from INF to start N2O, min	0 (−5 to +5)	4 (−10 to +18)	0.11*
Depth of sedation	1 (0 to 2)	1 (0 to 2)	0.38*
Additional centrally effective analgesics, X	n = 35	n = 340
Independent time of application	19 of 35	120 of 340	0.03†
Added <1.5 hr before N2O	6 of 35	38 of 340	0.30†
Unknown added time and <1.5 hr before N2O	9 of 35	53 of 340	0.12†

INF, intranasal fentanyl; N₂O, inhaled nitrous oxide; X= opioids or ketamine

^* Wilcoxon test;

^† Chi-square test.