Table 1.

Latest reported supramolecular peptide-based hydrogels with bioactive motifs.

Bioactive Sequence	Gelator	Function	Model	Ref.
RGD(S) and mimic	KFE-RGD KFE-RDG KFE-8	Cell adhesion	hMSC	[58]
	RADA16	Cell adhesion	3T3 cells	[59]
	G-Y sequence	Cell adhesion	L929 cells	[60]
	RGDSGAITIGC	Cell proliferation	3T3 cells	[61]
	E3-PA E3G3Ada-PA	Cell adhesion	3T3 cells	[62]
	Fmoc-FF Fmoc-RGD	Cell adhesion and Differentiation	3A6 cells Mice	[63]
	Fmoc-FF Fmoc-RGD	Cell delivery	Osteoblast Fibroblast Mice	[64]
	Fmoc-F5-Phe Fmoc-K(Fmoc)-RGD	Antimicrobial Cell adhesion	3T3 cells	[65]
	Silk fibroin Nap-FFRGD	Cell adhesion Angiogenesis	HUVEC Mice	[66]
	Silk fibroin Nap-FFRGD	Cell adhesion Osteogenesis	mBMSC Mice	[67]
	Collagen-like peptide	Neuronal cell maturation	Neuronal-glial cells	[68]
	Fmoc-FFβAR(K)βA-OH Fmoc-FFβAR(K)βA-NH2	Cell adhesion	MSC-P5, N2a, A549 cells	[69]
	Fmoc-FFGGRGD	Inhibition of β1-integrin, FAK and Akt expression	Tenon’s capsule fibroblasts	[70]
	Fmoc-FRGDF Agarose	Laminin and fibronectin mimic	-	[71]
	C16-V3A3E3E3RGDS C16-V3A3K3SVVYGLR C16-V3E3DGEA	Osteogenesis and angiogenesis	hAMSC, HUVEC	[72]
	Fmoc-FRGDF Fmoc-PHSRN	Cell adhesion	HMFC	[73]
	E1Y9-ALK E1Y9-RGDS E1Y9-DGR E1Y9-PRG	Osteogenesis	MC3T3-E1 cells	[74]
LDV	fFL and fFLDV	Cell adhesion	L929 cells	[75]
PHSRN	Fmoc-FRGDF Fmoc-PHSRN	Cell adhesion	HMFC	[73]
IKVAV	RADA4GGSIKVAV	Neuronal stem-cell delivery Anti-inflammatory	hMgSC Mice	[76]
	Fmoc-DIKVAV	Neuronal cell differentiation	Mice	[77]
	Fmoc-DDIKVAV	Neuronal cell differentiation	hPSC Mice	[78]
	IKVAV-PA	Neuronal cell differentiation	hESC Mice Human temporal bone	[79]
	IKVAV-PA	Neuronal cell differentiation	BMSC	[80]
	IKVAV-PA YRSRKYSSWYVALKR	Spinal cord injury repair (laminin and FGF2 mimicry)	Mice	[81]
	Fmoc-DIKVAV Agarose	Laminin and fibronectin mimic	-	[71]
	Fmoc-IKVAV Fmoc-YIGSR	Neuronal cell growth	C6 cells SHSY5Y cells	[82]
YIGSR	KLD-IKVAV KLD-YIGSR	Vasculogenesis	HUVEC, hMS cells	[83]
	Nap-GFF(p)YIGSR	Anticancer Self-assembly directly on cells	HeLa cells	[84]
	Fmoc-IKVAVFmoc-YIGSR	Neuronal cell growth	C6 cells SHSY5Y cells	[82]
YSV	FKFEYYSV	Anticancer	A549 cancer cells	[85]
	Taxol-EYSV	Anticancer	HeLa, A2780 cells Mice	[86]
	Nap-GffyGYSV	Anticancer	BEL-7402, HeLa, MCF-7 cells Mice	[87]
	Nap-Gff(p)YSV	Anticancer Self-assembly directly on cells	HeLa, A549 cells	[88]
	Nap-GFF(p)YSV	Anticancer Self-assembly directly on cells	HeLa cells	[84]
HAV	Fmoc/Nap-HAVDI	Cell adhesion	C6, L929 cells	[89]
	HAV-PA E-PA	Chondrogenesis	rMSC	[90]
	KLD-12	Chondrogenesis	hMSC	[91]
SVVYGLR	RADA16	Angiogenesis	HCN-A94-2 cells Zebrafish	[92]
	C16-V3A3E3E3RGDS C16-V3A3K3SVVYGLR C16-V3E3DGEA	Osteogenesis and angiogenesis	hAMSC, HUVEC	[72]
DGEA	C16-V3A3E3E3RGDS C16-V3A3K3SVVYGLR C16-V3E3DGEA	Osteogenesis and angiogenesis	hAMSC, HUVEC	[72]
KTT	C16KTTβAH	Collagen production	MCF-7, MDA-MB-231, HDFa cells	[93]
βAH	C16KTTβAH	Anticancer	MCF-7, MDA-MB-231, HDFa cells	[93]
ALKRQGRTLYGF	E1Y9-ALK E1Y9-RGDS E1Y9-DGR E1Y9-PRG	Osteogenesis	MC3T3-E1 cells	[74]
DGRDSVAYG	E1Y9-ALK E1Y9-RGDS E1Y9-DGR E1Y9-PRG	Osteogenesis	MC3T3-E1 cells	[74]
PRGDSGYRGDS	E1Y9-ALK E1Y9-RGDS E1Y9-DGR E1Y9-PRG	Osteogenesis	MC3T3-E1 cells	[74]