Table 3.
Adjusted Associations between Pre-FMP Psychosocial and Health-Related Predictors and High Depressive Symptoms during the Post-FMP (Postmenopause) (N=924, Number of observations=6,240)
| Model* | CES-D≥16 during postmenopause OR (95% CI) |
p-value |
|---|---|---|
| Pre-FMP CES-D trajectory group | ||
| Consistently low CES-D scores (REF) | --- | --- |
| Mid-level CES-D scores | 3.59 (2.64–4.88) | <.0001 |
| High CES-D scores | 14.73 (9.26–23.42) | <.0001 |
| Time (years) | 0.94 (0.92–0.96) | <.0001 |
| Age at baseline (years) | 0.95 (0.90–1.00) | 0.05 |
| Race/Ethnicity | ||
| White (REF) | --- | --- |
| Black | 1.37 (0.95–1.98) | 0.09 |
| Chinese | 1.21 (0.62–2.39) | 0.58 |
| Hispanic | 0.76 (0.24–2.37) | 0.63 |
| Japanese | 1.69 (0.81–3.51) | 0.16 |
| Education at baseline | ||
| Less than high school | 1.45 (0.80–2.63) | 0.22 |
| High school/some college | 0.86 (0.64–1.16) | 0.34 |
| College/more than college (REF) | --- | --- |
| Anxiety symptom score ≥ 4 at ≥ 50% of visits prior to FMP | 1.46 (1.02–2.10) | 0.04 |
| Social support (AUC) prior to FMP | 0.94 (0.90–0.98) | 0.004 |
| Sleep problems reported at ≥ 50% of visits prior to FMP | 1.35 (1.01–1.81) | 0.04 |
| Poor role physical score at ≥ 50% of visits prior to FMP | 1.78 (1.30–2.44) | 0.0003 |
| VMS at ≥ 50% of visits prior to FMP | 1.67 (1.26–2.23) | 0.0004 |
| History of any childhood maltreatment | 1.40 (1.07–1.83) | 0.01 |
FMP, Final Menstrual Period, CES-D, Center for Epidemiologic Studies-Depression scale; OR, Odds Ratio; CI, Confidence Interval; REF, referent group; AUC, Area Under the Curve; VMS, Vasomotor symptoms.
a
Adjusted for site. Significant p-values in bold font.