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. 2022 Jul 2;27(13):4272. doi: 10.3390/molecules27134272

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Origanum syriacum exhibits neuroprotective activities on fast excitatory neurotransmission in the central nervous system. Origanum syriacum regulates the glutamatergic neurotransmission system by stabilizing the desensitized/deactivated conformation of the glutamate receptor AMPAR, thus reducing its activity and decreasing the risk of neurotoxicity. Origanum syriacum also restores cholinergic neurotransmission by inhibiting the activity of AChE and preventing the hydrolysis of acetylcholine to choline and acetate. OS: Origanum syriacum; AMPAR: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; AChE: acetylcholinesterase enzyme.