Figure 9.

Antiviral activity of OFE formulations against HSV-1. Different assays were performed in order to evaluate anti-HSV-1 activity. Hydrogel and cream formulations interfered with the early stages of infection, acting in co-treatment and virus pre-treatment assays, although they did not exhibit any relevant antiviral activity either in cell pre-treatment or post-treatment tests. Statistical analyses were determined by ANOVA with Dunnett’s test for multiple comparisons. Significances are referred to as the negative control (−). **** p < 0.0001.