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Antiviral activity of OFE formulations against acyclovir-resistant HSV-1. Hydrogel and cream formulations were able to reduce the viral infection by acting in co-treatment and virus pre-treatment assays. Statistical analyses were determined by ANOVA with Dunnett’s test for multiple comparisons. Significances are referred to as the negative control (−). **** p < 0.0001; ns: non-significant.
