Table 2.
Changes in clinical parameters before and after CR and PR.
| Variable | Caloric Restriction (n = 11) | Protein Restriction (n = 10) | CR vs. PR | p, CR vs. PR | ||||
|---|---|---|---|---|---|---|---|---|
| Before | After | p | Before | After | p | Effect | Effect | |
| BMI, mean (SD), kg/m2 | 32.0 (5.4) | 29.9 (5.1) | <0.0001 | 29.1 (8.2) | 27.3 (7.0) | 0.010 | 0.3 | 0.05 |
| Insulin, mean (SD), pmol/L | 77.6 (53.3) | 73.3 (37.8) | 0.96 | 71.4 (57.8) | 71.9 (37.3) | 0.99 | 3.8 | 0.37 |
| CPK, mean (SD), µkat/L | 1.9 (1.2) | 1.0 (0.4) | 0.04 | 2.1 (1.2) | 1.0 (0.3) | 0.03 | −0.2 | 0.0001 |
| CRP, mg/L | 9.2 (5.5) | 3.9 (3.8) | 0.0002 | 8.5 (5.3) | 2.6 (2.3) | 0.0041 | −0.6 | 0.48 |
| Free fatty acids, mean (SD) * | 0.7 (0.2) | 0.5 (0.1) | 0.02 | 0.9 (0.2) | 0.7 (0.2) | 0.04 | 0 | 0.48 |
| Glycerol, mean (SD) * | 3.0 (1.3) | 1.9 (0.5) | 0.004 | 1.7 (0.9) | 1.1 (0.6) | 0.03 | 0.5 | 0.0001 |
| Urinary creatinine, mean (SD) * | 6.0 (2.3) | 6.4 (2.3) | 0.37 | 4.9 (2.0) | 5.8 (5.2) | 0.91 | −0.5 | 0.01 |
| Urinary urea, mean (SD) * | 345.7 (150.6) | 347 (144.5) | 0.99 | 247 (85.1) | 207.9 (99.6) | 0.62 | −42.0 | <0.0001 |
| Hb, mean (SD), g/L | 133 (10) | 132 (9) | 0.26 | 135 (11) | 134 (8) | 0.18 | 0 | 0.50 |
| Ht, mean (SD), % | 41.0 (3.5) | 40.4 (3.1) | 0.18 | 41.4 (4.7) | 41.1 (4.0) | 0.09 | 0.3 | <0.0001 |
(* mmol/L); p: p-value.