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Crystal structures of Mpro in complex with boceprevir (a), telaprevir (b), MG-78 (c), and MG-131 (d). Crystal structure of EV-A71 3Cpro (e) and CVB3 3Cpro (f) in complex with MG-78. The 2Fo-Fc OMIT maps are contoured at 1.5 σ, except for panels (a and f, which are contoured at 1.0 σ.
