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. 2022 Jul 4;27(13):4297. doi: 10.3390/molecules27134297

Figure 2.

Figure 2

Active site configuration of human (A) MAO-A (PDB structure 2Z5X) with harmine and (B) MAO-B (PDB structure 1OJ9) with 1,4,-diphenyl butene, depicting key amino acids lining the enzyme active site. (C) Overlaid view of MAO-A and MAO-B substrate binding site. Harmine and 1,4,-diphenyl butene are selective reversible inhibitors of MAO-A and MAO-B, respectively.