Table 4.
Coumarin natural product inhibitors of MAO-A and MAO-B.
| Compounds | Source | MAO-A | MAO-B | SI | Enzyme Source | References | ||
|---|---|---|---|---|---|---|---|---|
| IC50 (μM) | Ki (μM) | IC50 (μM) | Ki (μM) | MAOA/B | ||||
| Geiparvarin [84] | Geijera parviflora | 27 | 0.144 | 187.5 | B | [142] | ||
| Desmethylgeiparvarin [85] | Geijera parviflora | 24 | 0.028 | 857.1 | B | [142] | ||
| 2-Methoxy-3-(1,10-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one [86] | Gentina lutea | >100 | -- | 2.9 | 1.1 | >34.5 | B | [129] |
| 7-(6′R-Hydroxy-3′,7′-dimethyl-2′E, 7′-octadienyloxy) coumarin [87] | Dictamnus albus | 1.3 | -- | 0.5 | 0.46 | 2.6 | A | [141] |
| Auraptene [88] | Dictamnus albus | 34.6 | -- | 0.6 | 0.83 | 57.6 | A | [141] |
| Decursin [89] | Angelica gigas | 0.6 | 70.5 | 0.0085 | F | [142] | ||
| Anisucoumaramide [90] | Clausena anisum-olens | >100 | 0.143 | 699.3 | F | [143] | ||
| Osthenol [91] | Angelica pubescens | 0.74 | 0.26 | >60 | -- | >0.012 | F | [144] |
| Bakuchicin [92] | Angelica pubescens | 1.78 | 5.44 | 0.32 | F | [144] | ||
| Isopsoralen [93] | Angelica pubescens | 0.88 | 0.46 | 2.73 | 0.32 | F | [144] | |
| Umbelliferone [94] | Angelica decursiva | 39.16 | 147.37 | 0.26 | F | [145] | ||
| 6-Formylumbelliferone [95] | Angelica decursiva | 3.23 | 3.05 | 15.31 | 6.81 | 0.21 | F | [145] |
Note: natural products tested on total MAO are not listed. Enzyme source: A = mouse brain crude mitochondrial fraction; B = rat brain mitochondrial MAOs; F = recombinant human MAO-A and -B.