Table 3.
Compound/Plant | Extract/Fraction | Concentration (µg/mL) | % AChE Inhibition | IC50 (µg/mL) |
---|---|---|---|---|
Galantamine | Standard | 1000 | 95.67 ± 2.52 | 5.0 |
500 | 87.33 ± 2.52 | |||
250 | 82.67 ± 3.06 | |||
125 | 77.00 ± 3.00 | |||
Chrozophora
tinctoria |
MEC | 1000 | 83.33 ± 3.51 | 40 |
500 | 73.00 ± 3.00 | |||
250 | 68.33 ± 4.51 | |||
125 | 61.00 ± 2.00 | |||
NBFC | 1000 | 73.33 ± 3.06 | 110 | |
500 | 65.00 ± 2.65 | |||
250 | 57.67 ± 2.08 | |||
125 | 50.33 ± 2.52 |
Values are expressed as mean ± SEM. Statistical significance was determined using IC50 values through Biostata software. IC50 = half-maximal inhibitory concentration; MEC= methanolic extract of C. tinctoria; AChE = Acetylcholinesterase; NBFC = n-butanol fraction of Chrozophora tinctoria.