Table 6.
Diarrheal/laxative activity of n-butanol fraction C. tinctoria in metronidazole induced constipa-tion in pigeons.
| Samples | Dose g/kg mL/kg (P/O) |
First Stool/Latency Time (Minutes) |
Total Number of Stools | Number of Wet Stools | Weight of Stools (Grams) |
Percent of Wet Stool (%) |
|---|---|---|---|---|---|---|
| NBFC + DW | 1 | 28.33 ± 2.52 | 17.00 ± 3.00 | 10.33 ± 1.53 | 13.37 ± 1.96 | 61.03 ± 2.87 |
| 2 | 26.33 ± 3.51 | 19.00 ± 2.00 | 14.33 ± 1.53 | 16.13 ± 2.70 | 75.45 ± 1.54 | |
| 3 | 23.33 ± 2.52 | 20.00 ± 1.00 | 16.67 ± 1.15 | 17.17 ± 2.16 | 83.31 ± 2.96 | |
| Metronidazole (7 mg/kg) was administered (P.0) 30 min before fractions/distilled water/castor oil | ||||||
| DW (−ive Control) | 6 | 73.33 ± 2.52 | 9.33 ± 2.52 | 00 ± 00 | 8.27 ± 1.96 | 00 ± 00 |
| Castor oil (+ive Control) | 6 | 20.33 ± 2.52 *** | 22.00 ± 2.00 *** | 18.33 ± 1.53 *** | 18.67 ± 2.36 *** | 83.43 ± 2.23 *** |
| NBFC + METRO | 1 | 29.33 ± 1.53 *** | 15.33 ± 0.58 ** | 7.67 ± 0.58 *** | 12.37 ± 1.56 * | 50.00 ± 3.34 *** |
| 2 | 30.67 ± 2.08 *** | 17.00 ± 2.65 *** | 11.67 ± 1.53 *** | 15.53 ± 1.60 *** | 64.72 ± 2.09 *** | |
| 3 | 21.67 ± 2.52 *** | 17.00 ± 2.00 *** | 13.67 ± 1.53 *** | 16.10 ± 2.05 *** | 80.43 ± 1.75 *** | |
Data are presented as mean ± SEM; one-way ANOVA followed by Dunnett’s test was done to determine statistical significance where p ≤ 0.05 was considered statistically significant (* p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001). NBFC, n-butanol fraction of Chrozophora tinctoria; Metro, metronidazole; DW, distilled water; PO, per orally/by orally.