Table 7.
Diarrheal/laxative activity of methanolic extract of C. tinctoria in loperamide hydrochloride in-duced constipation in pigeons.
| Samples | Dose g/kg mL/kg (P/O) |
First Stool/Latency Time (Minutes) |
Total Number of Stools | Number of Wet Stools | Weight of Stools (Grams) |
Percent of Wet Stool (%) |
|---|---|---|---|---|---|---|
| MEC + DW | 1 | 28.67 ± 2.08 | 17.00 ± 2.00 | 9.00 ± 2.00 | 13.27 ± 1.72 | 52.50 ± 5.63 |
| 2 | 27.33 ± 2.52 | 18.33 ± 2.52 | 13.00 ± 2.00 | 14.23 ± 2.06 | 70.80 ± 1.82 | |
| 3 | 25.00 ± 2.00 | 20.33 ± 0.58 | 15.00 ± 3.00 | 17.37 ± 2.07 | 73.57 ± 12.91 | |
| Loperamide hydrochloride (4 mg/kg) was administered (P.0) 30 min before fractions/distilled water/castor oil | ||||||
| DW (-ive Control) | 6 | 70.33 ± 2.52 | 8.33 ± 2.52 | 00 ± 00 | 7.50 ± 2.29 | 00 ± 00 |
| Castor oil (+ive Control) | 6 | 17.33 ± 2.52 *** | 16.00 ± 2.00 ** | 14.33 ± 1.53 *** | 15.07 ± 1.27 *** | 89.74 ± 2.78 *** |
| MEC + Lopr | 1 | 38.00 ± 3.00 *** | 11.33 ± 2.52 | 4.33 ± 1.53 *** | 8.90 ± 1.65 | 37.51 ± 4.86 *** |
| 2 | 25.00 ± 2.52 *** | 13.67 ± 1.53 * | 7.67 ± 1.53 *** | 11.00 ± 0.95 | 55.71 ± 5.15 *** | |
| 3 | 28.33 ± 2.52 *** | 13.67 ± 1.53 * | 10.00 ± 1.00 *** | 12.77 ± 1.37 ** | 73.15 ± 2.44 *** | |
Data are represented as mean ± SEM. The data were analyzed by one-way ANOVA followed by Dunnett’s test using GraphPad Prism version 6.01; p ≤ 0.05 was considered significant (* p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001). MEC, methanolic extract of Chrozophora tinctoria; Lopr, loperamide hydrochloride; DW, distilled water; PO, per orally/by orally.