Table 1.
Effect of BC on hippocampal biomarkers.
| Groups | ACHE (μmol of Acetylthiocholine Iodide/min/mg of Protein) | GSH (μmol/L/mg of Protein) | TBARS (μM/mg of Protein) |
|---|---|---|---|
| Normal | 159.73 ± 29.05 | 35.68 ± 3.47 | 1.05 ± 0.16 |
| NA-STZ | 311.21 ± 26.58 a | 23.53 ± 2.54 a | 1.67 ± 0.12 a |
| BC (50) | 227.11 ± 18.82 a,b | 31.41 ± 2.45 b | 1.18 ± 0.16 b |
| BC (100) | 234.56 ± 20.97 a,b | 33.51 ± 2.36 b | 1.05 ± 0.22 b |
| DP (1) | 231.29 ± 22.60 a,b | 35.88 ± 1.10 b | 1.01 ± 0.17 b |
Digits in parenthesis indicated dose in mg/kg. Data were expressed as mean ± SD; n = 12 rats. a p < 0.05 vs. normal group; b p < 0.05 vs. VaD group. Abbreviations: AChE, acetylcholinesterase; BC, beta-carotene; DP, donepezil; GSH, reduced glutathione; NA, nicotinamide; STZ, streptozotocin; TBARS, thiobarbituric acid reactive substances.