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. 2022 Jun 23;27(13):4054. doi: 10.3390/molecules27134054

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of coumarin derivatives on the release of AA and TXA2 from human platelets. Human PRP was treated with 10 ppm of coumarin derivatives for 1 h. Purified plates were isolated, and 10 μM ADP and 3 μM fibrinogen were added for 30 min. Contents of AA (A) and TXA2 (B) were analyzed using an enzyme immunoassay (n = 3). * p < 0.05 compared with the control group. # p value < 0.05 for PRP treated with indicated compound followed by ADP stimulation compared with PRP stimulated with ADP alone.