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The molecular mechanism of β- and γ-secretase for the processing of APP. The extracellular amyloid deposits are the primary cause of AD. The natural compounds may be alternative agents that have β- and γ-secretase inhibition for the management of AD (APP—amyloid precursor protein, AICD—APP intracellular domain, Aβ—β-amyloid, ROS—reactive oxygen species).
