Table 1.

List of several natural compounds that have potential to inhibit AChE, BuChE, BACE1 and MAOs activity during in silico, in vitro, and in vivo studies.

S.No.	Compound	Pub Chem ID	Properties	Work Type	Therapeutic Actions/Function	Reference
1.	Apigenin	5280443	Antioxidant and antiinflammatory	in vitro	Decrease Aβ burden	[1,81]
				in vivo (mouse model)	induced neurogenesis
2.	Dibenzo[1,4,5]thiadiazepine	71358659	antioxidant	in vitro (neuroblastoma cells)	neuroprotective and antioxidant properties	[82]
3.	Berberine	2353	anti-inflammatory	in vitro (rat model)	inhibition of AChE	[83,84]
4.	Catechin	9064	antioxidant	in vivo (rat model of AD)	inhibition of AChE	[85]
5.	Genistein	5280961	Antioxidant and anti-inflammatory	in silico and in vitro (model of AD)	inhibition of human monoamine oxidase A and B	[86,87]
6.	Hesperidin	10621	antioxidant and anti-inflammatory	in silico and in vivo (rat model of AD)	inhibition of BACE1 and Aβ aggregation	[88,89,90]
7.	Morin	5281670	antioxidant, anti-inflammatory and neuroprotective	(MC65 cells)	BACE1, γ-secretase, Aβ fibrillogenesis, amyloid plaque, and tau hyperphosphorylation	[91,92]
8.	Naringenin	932	anti-inflammatory	in vitro (rat model)	decrease inflammatory cytokines	[93]
9.	Withanone	21679027	neuroprotective	in vivo (rat model of AD)	decrease Aβ fibril formation	[1,94]
10.	Dehydroevodiamine	9817839	anti-inflammatory	rat brain slices against AD	inhibition of tau phosphorylation	[95]
11.	Huperzine A	449069	neuroprotective	Alzheimer transgenic mouse model	reduces the level of Aβ	[96]
12.	N-methylasimilobine	197017	Antioxidant	in vitro	inhibition of AChE	[97]
13.	Isorhynchophylline	3037048	neuroprotective	rat model	restore Aβ–induced cognitive impairment	[98]
14.	Palmatine	19009	anti-inflammatory and anti-neurodegenerative	in vitro, in vivo	inhibit tau aggregation	[99]
15.	Sanguinarine	5154	Antitumor properties	in vitro	inhibition of AChE	[100]
16.	Taspine	215159	anti-inflammatory	in vitro	inhibition of AChE	[101]
17.	Indirubin	10177	antioxidant and anti-inflammatory	in silico	inhibition of AChE	[102,103]
18.	Rutaecarpine	65752	anti-inflammatory	in silico	inhibition of Caspase 8	[104]
19.	Ajmalicine	441975	antihypertensive	in silico	inhibition of BACE1	[105]
20.	Resveratrol	445154	Antioxidant	in vitro and in vivo (AD models)	neuroprotective role in AD	[106]
21.	Curcumin	969516	antioxidant, anticarcinogenic, anti-inflammatory, antiangiogenic	in vivo and in vitro	inhibition of AChE	[107]
22.	Resveratrol	445154	Antioxidant	in vitro	inhibition of MAOA for AD treatment	[108]
23.	Genistein	5280961	Antioxidant and anti-inflammatory	in vitro	anti-AD activities	[70]
24.	Quercetin	5280343	Antioxidant	-	Anti-BACE1 Activity	[71]
25.	Ellagic acid	5281855	antioxidant, antimutagenic, and anticancer properties	in vitro	MAO inhibitor for ND treatment	[78]
26.	Chelerythrine	2703	anti-inflammatory	in vitro	MAO-A inhibitor	[79]