Table 1.

Patient Characteristics and Course

Patient	Age	Sex	Diagnosis	Months Since Diagnosis	Surgical Resection	Months Since RT	Number of Previous Chemotherapy Courses	Current Dexamethasone Use	Reolysin Dose Level	Number of Courses	Time to Progression, Days	Overall Survival, Days
1	10	F	DIPG	9.8	N	7.0	1	Y; 4 mg/day	1; 5 × 108 TCID50/kg	1.0	28	82
2	17	F	DIPG	10.0	N	4.1	3	Y; 3.5 mg/day	1; 5 × 108 TCID50/kg	2.0	48	60
3	14	F	GBM	13.3	Y	2.6	1	N	1; 5 × 108 TCID50/kg	1.8	33	134
4	13	F	GBM	10.1	Y	7.2	2	Y; 3.5 mg/day	1*; 3 × 108 TCID50/kg	1.0	20	26
5	17	M	MB	75.2	Y	10.6	5	N	1*; 3 × 108 TCID50/kg	2.0	55	529
6	15	F	GBM	38.1	Y	35.7	3	N	1*; 3 × 108 TCID50/kg	1.2	32	169

Reolysin Dose Level 1* refers to the revised dose level 1 following the treatment of the first three patients.