Table 4.
GS and risk of all-cause dementia 1.
| GS | MAP | WHIMS | CHAP-White | CHAP-Black | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
| GSAD | ||||||||
| T1 | Ref. | Ref. | Ref. | Ref. | ||||
| T2 | 1.12 (0.80, 1.58) | 0.51 | 1.28 (1.16, 1.41) | <0.001 | 1.55 (0.66, 3.66) | 0.32 | 2.41 (0.82, 7.12) | 0.11 |
| T3 | 1.81 (1.31, 2.51) | 0.0003 | 1.43 (1.30, 1.58) | <0.001 | 1.55 (0.55, 4.34) | 0.41 | 0.77 (0.28, 2.11) | 0.61 |
| Trend | 1.10 (1.05, 1.15) | <0.0001 | 1.05 (1.04, 1.06) | <0.0001 | 1.09 (0.92, 1.30) | 0.32 | 1.06 (0.94, 1.20) | 0.32 |
| GSAD-I | ||||||||
| T1 | Ref. | Ref. | Ref. | Ref. | ||||
| T2 | 1.45 (1.03, 2.02) | 0.03 | 0.99 (0.89, 1.09) | 0.764 | 1.12 (0.50, 2.53) | 0.78 | 1.84 (0.76, 4.46) | 0.18 |
| T3 | 1.43 (1.03, 1.99) | 0.03 | 1.11 (1.01, 1.23) | 0.026 | 1.86 (0.74, 4.71) | 0.19 | 0.66 (0.25, 1.77) | 0.41 |
| Trend | 1.06 (1.00, 1.14) | 0.06 | 1.02 (1.01, 1.04) | 0.014 | 1.15 (0.96, 1.39) | 0.14 | 0.88 (0.73, 1.07) | 0.20 |
| GSAD-C | ||||||||
| T1 | Ref. | Ref. | Ref. | Ref. | ||||
| T2 | 0.86 (0.62, 1.20) | 0.38 | 0.99 (0.90, 1.10) | 0.911 | 1.01 (0.41, 2.45) | 0.99 | 1.29 (0.41, 4.04) | 0.66 |
| T3 | 1.08 (0.79, 1.47) | 0.64 | 1.25 (1.13, 1.37) | <0.0001 | 2.08 (0.82, 5.27) | 0.12 | 0.57 (0.21, 1.55) | 0.27 |
| Trend | 1.06 (0.93, 1.22) | 0.36 | 1.08 (1.03, 1.12) | 0.001 | 1.54 (0.86, 2.74) | 0.15 | 1.06 (0.81, 1.38) | 0.68 |
1 Results from Cox proportional hazard (HR) or logistic (OR) regression models adjusted for age, sex (MAP, CHAP only), study center and randomization status (WHIMS only) and genotype platform (MAP) or PCs (CHAP, WHIMS). T1, T2, T3 indicate tertile 1, tertile 2 and tertile 3 GS scores, respectively.