Figure 2.

Correlation of metabolic biomarkers with anthropometric and clinical features. Leptin was positively correlated with BMI (A), FM (B), and VFI (C). Glucagon was positively correlated with BMI (D), FM (E), and VFI (F). Adiponectin was positively correlated with VFI (G). Adiponectin was positively correlated with ALSFRS‐R (H), while no significant correlation was found between leptin and ALSFRS‐R (I). Adiponectin was negatively correlated with ΔFRS (J) and DPR (K), and leptin was also negatively correlated with DPR (L). BMI, body mass index; FM, fat mass; VFI, visceral fat index; ALSFRS‐R, revised ALS Functional Rating Scale; ΔFRS, slope of reduction in ALSFRS‐R at baseline since symptom onset; DPR, rate of disease progression during follow‐ups.