Table 4.
The effects of antidepressants and Zn supplementation on synaptic zinc level in rats subjected to the OB + ZnD model using Timm staining.
| Brain Structure | Treatment | Mean ± SEM |
|---|---|---|
| OB ZnD NaCl | 155.66 ± 7.48 | |
| OB ZnD Esc 10 | 201.50 ± 5.05 ** | |
| PFC | OB ZnD Ven 10 | 197.44 ± 8.27 * |
| OB ZnD Esc 1 + Zn 5 | 195.25 ± 7.68 ** | |
| OB ZnD Ven 1 + Zn 5 | 183.66 ± 5.30 * | |
| OB ZnD NaCl | 157.70 ± 13.11 | |
| OB ZnD Esc 10 | 161.66 ± 13.19 | |
| Hp | OB ZnD Ven 10 | 153.25 ± 11.08 |
| OB ZnD Esc 1 + Zn 5 | 174.03 ± 13.92 | |
| OB ZnD Ven 1 + Zn 5 | 150.27 ± 13.32 | |
| OB ZnD NaCl | 155.0 ± 9.78 | |
| OB ZnD Esc 10 | 177.83 ± 6.83 | |
| Cerebellum | OB ZnD Ven 10 | 192.80 ± 6.32 ** |
| OB ZnD Esc 1 + Zn 5 | 204.22 ± 2.61 ** | |
| OB ZnD Ven 1 + Zn 5 | 215.58 ± 8.76 *** |
Data were analyzed using a one-way ANOVA and the Newman–Keuls multiple comparisons test; * p < 0.05; ** p < 0.01, *** p < 0.001.