Table 1.

Patient, intervention, comparator, and outcome (PICO) criteria for inclusion and exclusion.

	Included Criteria	Excluded Criteria
Population	Experiment in animals and humans	All non-human and non-animal studies
Intervention	Prenatal BPA exposure	Non-BPA exposure in mixed chemical treatments, transgenerational studies, or direct exposure
Comparator	Low and high doses relative to control
Outcome	Metabolic syndrome, glucose homeostasis distribution, lipid homeostasis distribution, diabetes mellitus, disrupted insulin release and level	All other non-metabolic complications or no determination of metabolic parameter outcomes