Table A1.

Mothers’ exposure to different doses of BPA and the effect on their offspring in childhood and adulthood for animal studies.

Reference	Effective Dose	Pregnant Mothers	Offspring Childhood		Offspring Adulthood
			Male	Female	Male	Female
[51]	2.5 µg/kg/day	No effect on lipid metabolism	NS foetus hepatic TG and TC content
[43]	1 and 100 µg/kg/day				Week 14
					↑ hepatic TG (1 and 1000 BPA) ↑ liver weight (1 BPA)	↑ hepatic TG (1000 BPA) ↑ liver weight (1000 BPA)
[43]	1 µg/kg/day				Week 14
					↑ hepatic TG ↑ glucagon ↑ fasting glucose ↑ insulin levels ↑ IPGTT ↑ IPITT	NS hepatic TG NS glucagon NS fasting glucose NS insulin levels NS IPGTT NS IPITT
[44]	5 μg/kg/day		4 weeks		10 and 21 weeks
			↓ BW	NS BW	↑ glucose clearance ↑ plasma ↑ TG ↑ FFA ↑ UC ↑ VLDL ↑ hepatic TC content NS TC NS HDL NS LDL	↑ BW (13, 14, 20, and 22 weeks) ↓ hepatic TG NS lipid parameters NS insulin NS glucose tolerance
[52]	100 μg/kg/day	NS BW	NS birth weight ↑ hepatic TG ↑ FFA NS body composition (fat/lean mass ratio)		↑ BW but NS ↑ energy intake but NS ↑ body composition (fat/lean mass ratio)
[55]	2.5 µg/Kg/day	↓ BW third week	↑ birth weight
[45]	0.5 or 50 µg/Kg/day		5 and 52 weeks
			↑ insulin secretion (0.5 BPA) ↓ insulin secretion (50 BPA)
[56]	0.5 and 5 mg /Kg/day					21 Months
						NS plasma triglyceride (0.5 and 5 mg/Kg/day) ↑ hepatic and muscular TG content (0.5 and 5 mg/Kg/day) ↓ plasma LMW adiponectin levels (5 mg/Kg/day)
[57]	10 μg/kg/day and 10 mg/kg/day		↓ Birth weight ↓ BW (PND 14 and PND 21)	NS birth weight	PND 98 to PND 117
					↑ BW and body fat content (PND 98 and PND 117)↑ insulin levels (10 μg/kg/day) NS fasting glucose level in both doses ↑ IPGTT (10 mg/kg/day) ↓ maximal glucose stimulated insulin release	NS fasting glucose level NS IPGTT
[53]	50 µg/ kg/day		↓ gWAT at PND 45 glucose intolerance at PND 35		↑ BW PND 70-170 NS food intake IR at PND 125
[54]	0.5 or 50 µg/kg/day	NS BW NS water and food intake	5 Weeks
			↑ plasma TG (0.5 µg/kg/day)	↑ plasma TG (50 µg/kg/day)
			52 Weeks
			↓ BW (0.5 µg/kg/day) IR (0.5 µg/kg/day) NS plasma TG NS cholesterol NS leptin NS adiponectin	↑ BW (50 µg/kg/day) NS plasma TG NS cholesterol NS leptin NS adiponectin
[47]	10 μg/kg/day				↑ hepatic TG levels at PND 196 ↑ BW at PND 196 ↑ insulin level at 28 weeks ↑ perigonadal fat pad weight at 28 weeks ↑ fasting blood glucose at 17 weeks but NS impaired glucose tolerance
[48]	1 and 10 µg/mL	NS BW NS food and water intake	↑ BW both doses (PND 7-100) ↑ Blood glucose ↑ insulin ↓ serum adiponectin at (10 µg/mL BPA) PND 50		↑ BW both doses (PND 7-100) ↑ blood glucose ↑ insulin ↓ serum adiponectin IR at (1 and 10 µg/mL BPA) PND 100
[58]	50 μg/kg/day		3 weeks NS BW NS blood glucose ↑ serum insulin 21 weeks ↑ BW ↑ insulin resistance impaired glucose tolerance in rats’ hepatic tissue
[26]	1 or 20 µg/kg diet BPA	Both low doses NS BW NS food intake			NS BW Impaired glucose tolerance ↑ plasma insulin NS leptin level	NS BW NS glucose tolerance ↑ plasma leptin
[59]	10 or 100 µg/kg/day	Glucose intolerance (10 µg/kg/day) ↑ insulin sensitivity ↑ leptin ↑ TG ↑ glycerol (100 µg/kg/day)			3 months NS insulin resistance NS glucose intolerance 6 months ↓ glucose tolerance ↑ insulin resistance ↓ BW (10 µg/kg/day) ↑ leptin (100 µg/kg/day)	3 months NS insulin resistance NS glucose intolerance
[49]	25 mg BPA/kg diet		Did not alter the expression of insulin or increase in glucagon expression in BPA-exposed foetal pancreatic islets
[60]	100 µg/kg/day		NS birth weight	NS birth weight	↓ BW 3-8 months impaired glucose tolerance 3 months glucose intolerance	↓ BW NS glucose tolerance
[61]	10 μg/kg/day and 10 mg/kg/day				16 to 21 weeks Both doses of BPA significantly impaired insulin secretion
[62]	50ng, 50µg, or 50mg BPA/kg				↓ ADP at 50 µg BPA/kg NS fat mass and body weight	↑ ADP ♀ (50 ng and 50 mg of BPA/kg diet) ↓ the mean baseline glucose and insulin levels (50 mg of BPA/kg diet) ↑ fat mass and body weight ↓ serum leptin ↓ insulin and HOMA-IR (50 mg of BPA/kg diet)
[63]	50 µg/kg/day				20 weeks ↑ BW ↑ epididymal and perirenal fat pads ↑ food intake NS fasting glucose and glucose tolerance test ↑ insulin and leptin levels impaired glucose homeostasis ↑ food intake
[64]	0.1 mg/L	NS BW NS food intake NS water intake	NS BW ↓ glucose metabolism
[65]	0.05mg/kg/day				↑ glucose level IR
[66]	2.5, 25, and 250µg/kg/day	NS BW NS plasma lipid profile (cholesterol, HDL, LDL, and TG)
[67]	20 and 40 µg/kg/day	↓ BW	↓ BW ↑ foetal serum leptin ↑ insulin levels in both treated groups

Increase (↑); decrease (↓) and non-significant relative to those in the control groups (NS). Empty cells mean the parameters were not examined in the studies.