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. 2022 Jun 23;11(13):1668. doi: 10.3390/plants11131668

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The synergistic anticancer effects of S. purpurea-root-acetone and 5-FU. (A) Effects of S. purpurea-root-acetone and 5-FU on cell survival, migration, proliferation, and apoptosis. (B) Trypan blue dye exclusion staining; 4T1 cancer cells incubated with S. purpurea-root-acetone and 5-FU. (C) Hoechst staining. S. purpurea-root-acetone- and 5-FU-induced apoptosis with DNA fragmentation was observed in 4T1 cells. (D) Clonogenic formation assay. Pretreatment with S. purpurea-root-acetone and 5-FU significantly suppressed the proliferation and colony formation of 4T1 cells. (E) The wound-healing assay. S. purpurea-root-acetone and 5-FU significantly inhibited cell migration. ** p < 0.01 and *** p < 0.001 compared with the control group.