Table 1.
Baseline characteristics of unmatched and matched cohorts
| Patient Characteristics | Entire Cohort, n=992 | Phosphate-Free Continuous KRT Solution, n=343 | Phosphate-Containing Continuous KRT Solution, n=649 | Propensity Score Matched Phosphate-Free Continuous KRT Solution, n=303 | Propensity Score Matched Phosphate-Containing Continuous KRT Solution, n=303 |
|---|---|---|---|---|---|
| Study periods | — | 1/2015–2/2016 | 3/2016–5/2018 | 1/2015–2/2016 | 3/2016–5/2018 |
| Demographics | |||||
| Age, yr, median (IQR) | 56 (13) | 56 (13) | 57 (14) | 58 (48–65) | 59 (49–66) |
| Men, n (%)a | 579 (58) | 218 (64) | 361 (56) | 182 (60) | 176 (58) |
| Race, n (%)a | White 912 (92), Black 76 (8), other 3 (0.4) | White 313 (91), Black 28 (8), other 2 (1) | White 599 (92), Black 48 (7), other 2 (1) | White 278 (92), other 25 (8) | White 278 (92), other 25 (8) |
| BMI, median (IQR)a | 33 (12) | 33 (10) | 33 (13) | 31 (26–38) | 30 (25–38) |
| Comorbidity | |||||
| Charlson index, mean (SD)a | 2.2 (1.8) | 2.3 (1.9) | 2.1 (1.7) | 2.1 (1.7) | 2.2 (1.7) |
| Elixhauser index, mean (SD) | 4.6 (1.8) | 4.5 (1.6) | 4.6 (1.8) | 4.4 (1.6) | 4.7 (1.8) |
| Prevalent CKD (ICD-10 diagnosis), n (%)a | 452 (46) | 170 (50) | 282 (43) | 144 (48) | 142 (47) |
| Acuity of illness | |||||
| Admission to MICU, n (%)a | 664 (67) | 211 (62) | 453 (70) | 197 (65) | 192 (63) |
| Admission ICU, n (%) | |||||
| Medical/pulmonary | 664 (67) | 211 (62) | 453 (70) | ||
| Surgical/trauma | 75 (8) | 27 (8) | 48 (7) | ||
| Cardiothoracic | 92 (9) | 43 (13) | 49 (8) | ||
| Cardiac/nonsurgical | 87 (9) | 40 (12) | 47 (7) | ||
| Transplant | 38 (4) | 12 (4) | 26 (4) | ||
| Surgical/general | 27 (3) | 9 (3) | 18 (3) | ||
| Neurosurgery/ neurology | 9 (1) | 1 (0) | 8 (1) | ||
| SOFA at ICU start, mean (SD)a | 13 (3) | 13 (4) | 13 (3) | 12.6 (3.5) | 12.6 (3.3) |
| Vizient expected LOS | 14 (8–19) | 15 (10–23) | 14 (8–19) | ||
| Total effluent CRRT dose, ml/kg per h, median (IQR)a | 36 (11) | 36 (13) | 37 (10) | 33 (28–43) | 35 (31–40) |
| Cumulative fluid balance from ICU admission to CRRT start, ml, median (IQR)a | 680 (0–3007) | 1179 (0–3546) | 545 (0–2520) | 1050 (0–3376) | 793 (0–2952) |
| Cumulative fluid balance from ICU admission to CRRT stop, ml, median (IQR) | 622 (–15–2254) | 635 (–165–2343) | 662 (0–2197) | 614 (–91–2306) | 614 (0–1780) |
| Cumulative fluid balance from ICU admission to ICU discharge, ml, median (IQR) | 382 (–52–2155) | 369 (–65–2024) | 402 (−52–2230) | ||
| Days from ICU admission to CRRT start, median (IQR) | 1.5 (0.5–3.8) | 1.7 (0.5–4.6) | 1.4 (0.5–3.6) | 1.6 (0.5–4.1) | 1.8 (0.6–4.2) |
| Days on CRRT, median (IQR)a | 7 (3–12) | 7 (2–12) | 7 (3–11) | 7 (2–11) | 7 (3–12) |
| Ventilator days prior to CRRT | 0.31 (9.4) | 0.02 (6.1) | 0.47 (3.3) | ||
IQR, interquartile range; BMI, body mass index; ICD-10, International Classification of Diseases 10th revision; MICU, medical intensive care unit; ICU, intensive care unit; SOFA, sequential organ failure score; LOS, length of stay; CRRT, continuous KRT.
a
Variables included in the propensity score matching and variables considered for the primary multivariable model.