Table 2.
Unadjusted study outcomes according to the continuous KRT solution group
| Study Outcomes | Phosphate-Free Continuous KRT Solution, n=343 | Phosphate-Containing Continuous KRT Solution, n=649 | P Value |
|---|---|---|---|
| Primary outcome | |||
| Ventilator-free days at 28 d, median (IQR) | 21 (16–25) | 22 (17–25) | 0.20a |
| Secondary outcomes | |||
| Total hospital LOS, d, median (IQR) | 16 (5–25) | 12 (5–22) | 0.01a |
| Total ICU LOS, d, median (IQR) | 10 (3–23) | 8 (3–15) | 0.01a |
| Hospital mortality, n (%) | 213 (62) | 426 (66) | 0.23b |
| Other outcomes | |||
| Total days on ventilator, median (IQR) | 6 (2–12) | 4 (2–8) | 0.01a |
| Hypophosphatemia <2.5 mg/dl, n (%) | 194 (58) | 135 (22) | 0.01b |
| Severe hypophosphatemia <1 mg/dl, n (%) | 6 (2) | 79 (1) | 0.37b |
| Median phosphate level during CRRT, mg/dl, median (IQR) | 3.7 (3.1–4.7) | 4.4 (3.7–5.3) | 0.01a |
| Minimum phosphate level during CRRT, mg/dl, median (IQR) | 2.3 (1.8–3.9) | 3.4 (2.6–4.6) | 0.01a |
| Total phosphate replacement during CRRT, mmol, median (IQR) | 62 (0–302) | 0 (0–8) | 0.01a |
| Median ionized calcium | 3.15 (1.16) | 3.4 (1) | 0.01c |
| Positive ketones, n (%) | 53 (43) | 90 (40) | 0.60b |
| Tracheostomy, n (%) | 25 (7) | 19 (3) | 0.01b |
| Discharge disposition, n (%) | |||
| Alive/home | 196 (32) | 186 (29) | 0.27b |
| Rehabilitation facility | 19 (6) | 33 (5) | |
| Other | 5 (2) | 3 (1) | |
Continuous data are reported as median (IQR), and categorical data are reported as counts and percentages. IQR, interquartile range; LOS, length of stay; ICU, intensive care unit; CRRT, continuous KRT.
a
Wilcoxon rank sum test.
b
Chi-squared test.
c
Independent samples t test.