Table 2.
MicroRNAs in sepsis-associated AKI
| MicroRNA | Sample | Control | Target Pathway | Reference | Title of the Reference |
|---|---|---|---|---|---|
| Increased | |||||
| miR-107 | CECs | Healthy volunteers, nonseptic AKI, septic non-AKI |
DUSP7 | (86) | MiR-107 induces TNF-α secretion in endothelial cells causing tubular cell injury in patients with septic AKI |
| miR-4321 | Serum | Healthy volunteers, septic non-AKI |
AKT1, mTOR, NOX5 | (87) | Differentially expressed miRNAs in sepsis-induced AKI target oxidative stress and mitochondrial dysfunction pathways |
| miR-4270 | Serum | Healthy volunteers, septic non-AKI |
PPARGC1A, AKT3, NOX5, PIK3C3, WNT1 | (87) | Differentially expressed miRNAs in sepsis-induced AKI target oxidative stress and mitochondrial dysfunction pathways |
| miR-29a | Serum | Septic non-AKI | Unknown | (88) | Predictive value of miRNA-29a and miRNA-10a–5p for 28-day mortality in patients with sepsis-induced AKI |
| miR-10a-5p | Serum | Septic non-AKI | Unknown | (88) | Predictive value of miRNA-29a and miRNA-10a–5p for 28-day mortality in patients with sepsis-induced AKI |
| miR-26b | Urine | Septic non-AKI | Unknown | (89) | Urinary miR-26b as a potential biomarker for patients with sepsis-associated AKI: a Chinese population-based study |
| miR-210 | Plasma | Healthy volunteers | Unknown | (90) | Expression patterns and prognostic value of miR-210, miR-494, and miR-205 in middle-aged and old patients with sepsis-induced AKI |
| miR-494 | Plasma | Healthy volunteers | Unknown | (90) | Expression patterns and prognostic value of miR-210, miR-494, and miR-205 in middle-aged and old patients with sepsis-induced AKI |
| miR-152–3p | Serum | Healthy volunteers | ERRFI1, STAT3 | (91) | A novel role of the miR-152–3p/ERRFI1/STAT3 pathway modulates the apoptosis and inflammatory response after AKI |
| miR-452 | Serum, Urine | Healthy volunteers, septic non-AKI |
Unknown | (92) | Discovery and validation of miR-452 as an effective biomarker for AKI in sepsis |
| miR-34b–5p | Serum | Healthy volunteers | AQP2 | (93) | miR-34b–5p promotes renal cell inflammation and apoptosis by inhibiting AQP2 in sepsis-induced AKI |
| Decreased | |||||
| miR-205 | Plasma | Healthy volunteers | Unknown | (90) | Expression patterns and prognostic value of miR-210, miR-494, and miR-205 in middle-aged and old patients with sepsis-induced AKI |
| miR-15a–5p | Serum | Healthy volunteers, septic non-AKI |
mTOR signaling | (94) | The miR-15a–5p-XIST-CUL3 regulatory axis is important for sepsis-induced AKI |
| miR-15b–5p | Serum | Healthy volunteers, septic non-AKI |
mTOR signaling | (94) | The miR-15a–5p-XIST-CUL3 regulatory axis is important for sepsis-induced AKI |
| miR-16–5p | Serum | Healthy volunteers, septic non-AKI |
PI3K/AKT/mTOR signaling | (94) | The miR-15a–5p-XIST-CUL3 regulatory axis is important for sepsis-induced AKI |
| miR-376b | Urine | Healthy volunteers, septic non-AKI |
NFKBIZ | (95) | The negative feedback loop of NF-κB/miR-376b/NFKBIZ in septic AKI |
| miR-150–5p | Serum | Healthy volunteers | MEKK3/JNK pathway | (96) | MiR-150–5p protects against septic acute kidney injury via repressing the MEKK3/JNK pathway |
miRNA, microRNA; CECs, circulating endothelial cells; DUSP7, dual-specificity phosphatase 7; AKT1, AKT serine/threonine kinase 1; mTOR, mammalian target of rapamycin; NOX5, NADPH oxidase; PPARGC1A, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3; WNT1, WNT family member 1; ERRFI1, ERBB receptor feedback inhibitor 1; STAT3, signal transducer and activator of transcription 3; AQP2, aquaporin-2; PI3K, phosphatidylinositol-3-kinase; NFKBIZ, NF-κB inhibitor ζ; MEKK3, mitogen-activated protein kinase 3; JNK, c-Jun N-terminal kinase.