Table 1.

Mechanisms of hyponatremia associated with cancer immunotherapy according to agent class

Immune Checkpoint Inhibitors			T Cell Transfer Therapy		mAbs	Immunomodulators
Programmed Cell Death Protein 1/Programmed Cell Death Ligand 1 Inhibitors/Anticytotoxic T Lymphocyte–Associated Protein 4			Tumor-Infiltrating Lymphocyte Therapy	Chimeric Antigen Receptor T Cell Therapy		IL-2	IFNα
SIAD	Cortisol deficiency (1) Hypophysitis: panhypopituitarism,a isolated ACTH deficiencyb (2) Adrenalitis,b primary adrenal insufficiency	Hypothyroidism, thyroiditisb	SIAD	Hypovolemia, capillary leak syndrome	SIAD	Hypovolemia, capillary leak syndrome	SIAD

SIAD, syndrome of inappropriate antidiuresis; ACTH, adrenocorticotropic hormone.

^aMore common with anticytotoxic T lymphocyte–associated protein 4.

^bMore common with programmed cell death protein 1/programmed cell death ligand 1 inhibitors.