Table 2.
Association between APOL1 and biomarkers of kidney disease by risk allele status (zero, one, or two) and recessive, dominant, and additive models
| Biomarkers of Kidney Diseasea | Low eGFRb | Albuminuriac | Composite End Pointd |
|---|---|---|---|
| Frequency of APOL1 risk alleles, N (%) | |||
| 0 | 202/6210 (3.3) | 507/5259 (10) | 627/5225 (12) |
| 1 | 122/3797 (3.2) | 306/3105 (10) | 363/3083 (12) |
| 2 | 23/635 (3.6) | 79/519 (15) | 84/507 (17) |
| All | 347/10,642 (3.0)e | 892/8883 (10)f | 1074/8815 (12) |
| APOL1 models odds ratio (95% confidence interval) | |||
| Sample size, N | 9340g | 8526g | 8486g |
| Additive | 0.78 (0.52 to 1.19) | 1.39 (1.09 to 1.76) | 1.16 (0.93 to 1.45) |
| Dominant, 0 versus 1 or 2 risk alleles | 0.86 (0.67 to 1.11) | 1.12 (0.97 to 1.31) | 1.03 (0.90 to 1.19) |
| Recessive, 0 or 1 versus 2 risk alleles | 0.87 (0.52 to 1.47) | 1.63 (1.25 to 2.12) | 1.37 (1.06 to 1.78) |
For biomarkers of kidney disease, repeat measures for those with albuminuria or low eGFR were not performed, preventing confirmation of CKD; therefore, we used “biomarkers of kidney disease” to define these measures on a single screening.
Low eGFR is eGFR <60 ml/min per 1.73 m2 calculated using the Chronic Kidney Disease Epidemiology Collaboration (creatinine) equation (2009) without adjusting for the African American coefficient.
Albuminuria is a random spot urine albumin-creatinine ratio >30 mg/g.
The composite end point is low eGFR and/or albuminuria.
Missing data n=127 of 10,967 (1%).
Missing data n=1886 of 10,967 (17%).
Corresponds at main section and in genotype at the total of individual with zero risk allele, one risk allele, and two risk alleles.