Table 3.
APOL1 associations with albuminuria stratified by diabetes, hypertension, and HIV status
| Comorbidity Status | Albuminuria,a n/N (%) | Albuminuriaa Odds Ratio (95% Confidence Interval), Age+Sex–Adjusted Modelb | Albuminuriaa Odds Ratio (95% Confidence Interval), Fully Adjusted Modelc | Pinteraction term Value, Age+Sex–Adjusted Modelb |
|---|---|---|---|---|
| Diabetes | 0.31 | |||
| Absent | 745/8259 (9.0) | 1.68 (1.28 to 2.20) | 1.71 (1.30 to 2.26) | |
| Present | 131/523 (25.0) | 1.20 (0.53 to 2.74) | 1.06 (0.45 to 2.49) | |
| Hypertension | 0.04 | |||
| Absent | 383/5781 (6.6) | 1.94 (1.34 to 2.82) | 2.09 (1.43 to 3.05) | |
| Present | 509/3102 (16.4) | 1.30 (0.91 to 1.85) | 1.33 (0.92 to 1.92) | |
| HIV | 0.40 | |||
| Negative | 655/7508 (8.7) | 1.64 (1.22 to 2.19) | 1.72 (1.28 to 2.33) | |
| Positive | 202/1129 (17.9) | 1.28 (0.74 to 2.23) | 1.36 (0.78 to 2.40) |
a
Albuminuria is random spot urine albumin-creatinine ratio >30 mg/g.
b
Logistic mixed models were adjusted for age and sex as fixed variables.
c
Logistic mixed models were adjusted for site as a random variable and age, sex, body mass index, diabetes mellitus status, hypertension status, and HIV status as fixed variables. Some participants were excluded from the fully adjusted model due to missing data.