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. 2022 Jul 8;17(7):e0267331. doi: 10.1371/journal.pone.0267331

Fig 6. AT1aR knockout activated cAMP/PKA pathway.

Fig 6

A: Protein expressions of PKA, P-GSK-3β (ser9) and GSK-3β in adipose tissue. B: cAMP levels in adipose tissue. C: The proposed pathway for Ang II inhibiting adipose lipolysis. By binding to AT1R, Ang II activates inhibitory Gi which in turn reduces cAMP production. As a result, PKA activation is limited and HSL phosphorylation is decreased, leading to inhibitory of triglyceride hydrolysis. +p < 0.05 vs AT1aR-/—ND rats. Data were presented as Mean ± S.E.M. n = 6.