Table 2. Key Implementation messages: Addressing participants’ views on barriers and facilitators of COVID-19 vaccine uptake.

Factors influencing uptake	Opportunities to address this in primary care / the community	Considerations & Resources for practice:
Concerns about speed of vaccine roll out	Addressing fears directly about speed of vaccinxfe roll out	• Explain vaccination research process why this was quicker than anticipated. • Useful links to help guide this process from LSHTM [25] and in the COVID-19 Communication Handbook [26]
Concerns about the vaccines’ known and unknown effects on health	Tailored information, addressing how different ethnicities were involved in the study	• Discussing concerns and sharing information with specific information about the demographics of participants in the trials. • There is a short video [27] available from John Hopkins and a Key Questions article [28]
Information Sources of Participants	Understand previous misinformation exposure in order to address concerns directly.	• Seek to understand misinformation exposure and how this has informed current thinking and hesitancy around vaccination • The following provide suggestions about how to approach conversations countering conspiracy and misinformation: The Conspiracy Theory Handbook [29] and Tips on Countering Conspiracy & Misinformation [30] • Utilising communication tools [31] to express risks and benefits
Trust in healthcare professionals	Opportunity for information provision from trusted Health Care Professionals	• Opportunistic vaccine promotion during health contacts • For those unvaccinated and in at-risk categories, opportunity for discussion with healthcare professional
Social Influence–Impact of wider community	Channelling communication through communities & religious groups	• Identify trusted local leadership and engage in reaching local communities • Utilise local community locations and hubs, including religious centres, through in-reach community vaccination programme delivery. • Consider the use of community ambassadors or champions to encourage vaccination uptake [32] • This report [33] makes further suggestions for community engagement
Social Influence–Impact of closer group of family and friends	Utilising inter-generational information transfer	• Ensuring vaccination promotion messages reach patients across age-groups and encourage sharing of information provision with family members across generations. • Use of social media and platforms commonly used by younger age groups to circulate vaccine information • Information-giving in a diversity of digital formats more likely to appeal to younger people
Promotion of incentives for vaccination	Highlight incentives for vaccination such as travel and protection of family members	• Explore potential vaccination benefits and their impact for the patient.