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. 2022 Jul 1;2022:1244836. doi: 10.1155/2022/1244836

Figure 6.

Figure 6

Blocking PI3K compromised increase of miR-126 KD on apoptosis in lung cancer cells. (a) Two si-PI3KR2 vectors significantly decreased mRNA expression of PI3KR2 in A549 cells (∗∗P < 0.01, ∗∗∗P < 0.001, n = 4); (b) KD of PI3KR2 compromised increase of miR-126 KD on increase of caspase 3 mRNA expression in A549 cells (∗∗P < 0.01, n = 4); (c) KD of PI3KR2 compromised increase of miR-126 KD on increase of caspase 9 mRNA expression in A549 cells (∗∗P < 0.01, ∗∗∗P < 0.001, n = 4); (d) KD of PI3KR2 compromised increase of miR-126 KD on decrease of cell viability in A549 cells (∗∗P < 0.01, ∗∗∗P < 0.001, n = 4); (e) two si-PI3KR2 vectors and si-scramble vectors were transfected in H1650 cells, which indicated that two si-PI3KR2 vectors significantly decreased mRNA expression of PI3KR2 in H1650 cells (∗∗P < 0.01, ∗∗∗P < 0.001, n = 4); (f) KD of PI3KR2 compromised increase of miR-126 KD on increase of caspase 3 mRNA expression in H1650 cells (∗∗P < 0.01, ∗∗∗P < 0.001, n = 4); (g) KD of PI3KR2 compromised increase of miR-126 KD on increase of caspase 9 mRNA expression in H1650 cells (∗∗P < 0.01, n = 4); (h) KD of PI3KR2 compromised increase of miR-126 KD on decrease of cell viability in H1650 cells (∗∗P < 0.01, ∗∗∗P < 0.001, n = 4).