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. 2022 Jul 4;82:104087. doi: 10.1016/j.ebiom.2022.104087

Figure 2.

Figure 2

Oral supplementation of A. muciniphila protects Cold rats against AF. (A) Endocardial and surface electrograms recordings in response to burst pacing in Cold and Cold + A. muciniphila group. Supplementation with A. muciniphila reduced AF inducibility (B) and duration (C) in Cold rats (n = 10 per group). (D) Representative images of Masson's trichrome staining and the collagen volume fraction in the atria of Cold and Cold+A. muciniphila rats (n = 4 per group). Magnification × 200, scale bar = 50μm. (E) Representative bands and quantification of expressions of TGF-β1 and α-SMA in rats of Cold and Cold+A. muciniphila groups (n = 6 per group). AF inducibility (F) and AF duration (G) in Cold (n = 10) and Cold + pasteurised A. muciniphila group (n = 9). GAPDH was used for normalization. Data are expressed as mean ± SEM and compared by Student's t test (D and E) or Wilcoxon test (C and G). AF inducibility (B and F) was presented as numbers and compared by Fisher exact test.