Figure 3.

Inflammatory markers (OLINK inflammation panel) at diagnosis of diabetes in 805 islet autoantibody-positive patients in DiMelli. (a) The data were used to generate heatmaps and identify four clusters of patients. The most informative proteins in these clusters are indicated in the heatmap. Fasting C-peptide is shown on the right. (b) Frequency distribution of the four clusters within the CART-defined patient groups. (c) Fasting C-peptide concentrations in the group P1 and P3 patients stratified by inflammatory cluster. ADA, adenosine deaminase; CASP-8, caspase-8; FGF, fibroblast growth factor; IFNɣ, interferon-ɣ; IL, interleukin; MCP, monocyte chemoattractant protein; MMP, matrix metalloproteinase; TGF, transforming growth factor; TNF, tumour necrosis factor.