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. 2021 May 24;36(4):713–726. doi: 10.1007/s10557-021-07186-y

Table 2.

Specific information for core targets

Number Uniprot ID Gene name Protein name Counts
1 P12931 SRC Tyrosine-protein kinase Lck 19
2 P28482 MAPK1 Mitogen-activated protein kinase 1 17
3 P01111 NRAS GTPase NRas 16
4 P27361 MAPK3 Mitogen-activated protein kinase 3 15
5 P00533 EGFR Epidermal growth factor receptor 12
6 P06239 LCK Tyrosine-protein kinase Lck 12
7 Q06124 PTPN11

Tyrosine-protein phosphatase nonreceptor

type 11

11
8 Q02750 MAP2K1

Dual specificity mitogen-activated

protein kinase kinase 1

11
9 O60674 JAK2 Tyrosine-protein kinase JAK2 10
10 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 7
11 P09619 PDGFRB

Platelet-derived growth factor receptor

beta

6
12 P15056 BRAF Serine/threonine-protein kinase B-raf 6
13 Q16539 MAPK14 Mitogen-activated protein kinase 14 5
14 P00734 F2 Prothrombin 5
15 P08581 MET Hepatocyte growth factor receptor 5
16 P06493 CDK1 Cyclin-dependent kinase 1 4
17 P24941 CDK2 Cyclin-dependent kinase 2 3
18 P30556 AGTR1 Type-1 angiotensin II receptor 3
19 P11142 HSPA8 Heat shock cognate 71 kDa protein 3
20 Q15759 MAPK11 Mitogen-activated protein kinase 11 3
21 P04066 FUCA1 Tissue alpha-L-fucosidase 3
22 P16278 GLB1 Beta-galactosidase 3
23 P20839 IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 3
24 Q9NZQ7 CD274 Programmed cell death 1 ligand 1 2
25 P14780 MMP9 Matrix metalloproteinase-9 2
26 P08254 MMP3 Stromelysin-1 2
27 Q99558 MAP3K14 Mitogen-activated protein kinase kinase kinase 14 2
28 Q05586 GRIN1 Glutamate receptor ionotropic, NMDA 1 1
29 P19320 VCAM1 Vascular cell adhesion protein 1 1
30 P11309 PIM1 Serine/threonine-protein kinase pim-1 1
31 P17931 LGALS3 Galectin-3 1
32 P11362 FGFR1 Fibroblast growth factor receptor 1 1
33 P35916 FLT4 Vascular endothelial growth factor receptor 3 1