Table 2.

Mean hormonal determinations (FSH, LH, ratio LH/FSH, estradiol, ACTH, cortisol, 17-OH-P, DHE-S, androstendiona, T and FT) in prepubertal and early subgroups according to the BMI status (M, 95% CI)

	Control group (n = 132)	Obesity group (n = 165)	p values*
Prepubertal subgroup
FSH (UI/L)	1.5 (1.3–1.6)	1.6 (1.0–2.2)	0.754
LH (UI/L)	0.05 (0.04–0.06)	0.050 (0.03–0.06)	0.275
ratio LH/FSH	0.03 (0.03–0.04)	0.04 (0.03–0.04)	0.314
Estradiol (pg/mL)	9.1 (8.5–9.7)	9.5 (9.2–9.8)	0.126
ACTH (ng/L)	19.8 (15.9–23.6)	22.3 (19.3–25.3)	0.299
Cortisol (μg/dL)	8.6 (7.7–0.6)	8.1 (7.2–9.0)	0.421
17-OH-P (μg/L)	0.8 (0.6–1.0)	0.80 (0.7–0.8)	0.435
DHE-S (μg/dL)	61.0 (53.3–68.7)	71.7 (64.2–79.2)	0.253
Androstenedione (μg/L)	0.4 (0.3–0.5)	0.4 (0.3–0.4)	0.752
Testosterone (ng/mL)	0.1 (0.09–0.11)	0.11 (0.10–0.12)	0.674
FT (ng/L)	0.33 (0.27–0.39)	0.40 (0.32–0.48)	0.220

	Control group (n = 111)	Obesity group (n = 118)	p values*
Early puberty subgroup
FSH (UI/L)	3.7 (3.3–4.1)	3.8 (3.5–4.2)	0.529
LH (UI/L)	0.7 (0.5–0.9)	2.5 (2.0–2.9)	0.001
ratio LH/FSH	0.19 (0.15–0.24)	0.6 (0.5–0.7)	0.001
Estradiol (pg/mL)	24.6 (17.6–31.5)	31.0 (24.4–37.5)	0.310
ACTH (ng/L)	18.1 (14.9–21.1)	29.6 (24.8–34.3)	0.003
Cortisol (μg/dL)	9.2 (6.8–11.5)	11.5 (9.6–13.3)	0.389
17-OH-P (μg/L)	0.8 (0.7–1.0)	0.9 (0.7–1.1)	0.318
DHE-S (μg/dL)	69.6 (61.0–78.3)	143.8 (130.6–156.9)	0.001
Androstenedione (μg/L)	0.6 (0.5–0.7)	1.4 (1.2–1.6)	0.001
Testosterone (ng/mL)	0.14 (0.10–0.18)	0.23 (0.21–0.25)	0.001
FT (ng/L)	0.6 (0.4–0.7)	1.3 (1.1–1.3)	0.001

*Student’s t test