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. 2022 Jul 8;13:3938. doi: 10.1038/s41467-022-31055-3

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© The Author(s) 2022, corrected publication 2022

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Fig. 2 — a Quantile-quantile plot of fishHook p-values to assess significance of gene mutational burden after removing confounders. The p-values were obtained by comparing observed mutational rate to the right tail (one-sided) of the expected mutational rates derived from a gamma-Poisson model of genome-wide mutational density and the covariates replication timing, epigenetic state, and sequence context. In the first stage of CIRCLE, six significant genes were identified below a false-discovery threshold (FDR < 0.1). b Odds ratios (ORs) of response to ICB therapy in patients with a high or moderate impact mutation in the indicated gene as compared to patients that do not have a high or moderate mutation in the given gene (n = 272 patients). Error bars indicate the 95% confidence interval of the odds ratio. ORs greater than one indicate enrichment in responders and ORs less than one indicate enrichment in non-responders. Statistical significance was tested using a two-sided Wald’s test of coefficients with multiple-hypothesis correction (FDR < 0.2).