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. 2022 Jul 8;12:11667. doi: 10.1038/s41598-022-15859-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The PPI network of the predictive target genes of the top 10 DE-miRNAs. (a) The red rectangle represents the predicted upregulated gene of downregulated DE-miRNAs; (b) the bule rectangle represents the predicted downregulated gene of upregulated DE-miRNAs. The more node pairs, the darked the color is, which indicates the higher the rank of hub gene is. PPI protein–protein interaction, DE-miRNAs differentially expressed miRNAs.