Fig. 3.

The roles of phase separation in various cancers. (By Figdraw.). a In stem-like breast cancer cell model, the histone deacetylase HDAC7 binds near the transcriptional start site and to SEs of various oncogenes. b YTHDC1 undergoes LLPS via binding with m⁶A-mRNA, and the number of resulting nuclear condensates (nYACs) is greatly increased in acute myeloid leukemia (AML) cells. c In multiple myeloma (MM) cells, the 3’ IgH super-enhancer (SE) inserts near the MYC locus, driving the upregulation of MYC expression. d Mutant FERM domain of NF2 form phase-separated condensates with IRF3 and abrogates the antitumor immunity initiated by STING. e In lung cancer, the liquid-like YAP/TEAD/SRC-1 compartments in nucleus can broadly upregulate YAP transcription. f Glycogen accumulation and phase separation lead to the formation of Laforin-Mst1/2 complex, thus activate oncogenic YAP signaling