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. 2022 Jul 8;7:221. doi: 10.1038/s41392-022-01076-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Components and processes in normal transcription and SE-mediated transcriptional addiction of genes in cancer. a The normal transcription of a gene involves proper interactions among the promoter, RNA pol 2, coactivators, TFs and enhancers. b The SE condensates form a liquid-like complex via LLPS and may result in the transcriptional addiction of certain genes. c Detailed illustration of the IDR-IDR interaction that promotes SE formation