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. 2022 Jun 22;7(6):582–596. doi: 10.1016/j.jacbts.2022.02.008

Figure 4.

Figure 4

Effect of Epicardial RTX Application on Renal Injury and Inflammatory Biomarkers Post-Myocardial Infarction

Real-time PCR data showing (A, B)Kim1, (C, D)Ngal, (E, F)Il6, and (G, H)Il1b mRNA expressions in the renal cortex and medulla from Sham, CHF+Veh, and CHF+RTX rats. Sham group: n = 12 for A to H; CHF+Veh group: n = 14 for A to H; CHF+RTX group: n = 9 for A and C to H, n = 8 for B. Real-time PCR data showing the time-course for alterations in (I, J)Kim-1 and (K, L)Ngal mRNA expressions in renal cortex and medulla from Sham and CHF rats. (I, J) For 1 week, 4 weeks, 8 weeks, and 18 weeks, respectively, after surgery: Sham group, n = 6, 5, 7, and 12; CHF group, n = 8, 8, 8, and 12. (K, L) For 1 week, 4 weeks, 8 weeks, and 18 weeks, respectively, after surgery: Sham group, n = 6, 5, 6, and 12; CHF group, n = 8, 8, 6, and 12. ∗P < 0.05 vs Sham. †P < 0.05 vs CHF+Veh. Actb = actin-beta; Il6 = interleukin-6; Il1b = interleukin-1beta; Kim1 = kidney injury molecule 1; Ngal = neutrophil gelatinase–associated lipocalin; PCR = polymerase chain reaction; other abbreviations as in Figure 1.