Figure 5.

Hemodynamic Measurements After Acute Cardiac Afferent Activation and Chronic Cardiac Afferent Ablation in Response to Epicardial Application of BK

(A to E) Cardiac afferent activation caused exaggerated renal vasoconstriction in the post-MI rats. (F, G) Cardiac spinal afferent reflex ablation by RTX partially restored the decreased renal blood flow and reduced RVR in CHF rats. Sham group, n = 8; CHF+Veh group, n = 7; CHF+RTX group, n = 7. ∗P < 0.05 vs Sham. †P < 0.05 vs CHF+Veh. AP = arterial blood pressure; BK = bradykinin; HR = heart rate; MAP = mean arterial blood pressure; RF = renal blood flow; RVR = renal vascular resistance; other abbreviations as in Figure 1.