Table 1.

Blood Analysis in Sham, CHF+Vehicle, and CHF+RTX Rats

	Sham (n = 8)			CHF+Vehicle (n = 14)			CHF+RTX (n = 8)
	6-8 wk	12-14 wk	16-18 wk	6-8 wk	12-14 wk	16-18 wk	6-8 wk	12-14 wk	16-18 wk
Na, mmol/L	140.8 ± 1.1	140.6 ± 0.9	140.9 ± 1.1	140.1 ± 1.8	138.6 ± 1.8	140.7 ± 0.9	139.9 ± 1.3	137.7 ± 1.4	140.8 ± 0.7
K, mmol/L	4.10 ± 0.19	4.03 ± 0.23	4.00 ± 0.16	4.23 ± 0.28	4.14 ± 0.29	4.71 ± 0.25a	4.14 ± 0.22	4.07 ± 0.16	4.19 ± 0.26b
Cl, mmol/L	102.3 ± 2.1	101.8 ± 2.2	102.5 ± 2.5	101.5 ± 1.8	101.5 ± 1.3	102.5 ± 3.1	102.1 ± 1.6	102.3 ± 1.0	101.9 ± 1.5
iCa, mmol/L	1.23 ± 0.09	1.22 ± 0.13	1.20 ± 0.07	1.31 ± 0.09	1.32 ± 0.03	1.23 ± 0.06	1.21 ± 0.07	1.25 ± 0.07	1.19 ± 0.05
TCO2, mmol/L	25.4 ± 4.0	25.5 ± 3.8	25.9 ± 3.3	26.2 ± 1.7	26.3 ± 1.6	26.1 ± 3.0	25.6 ± 2.2	26.4 ± 1.8	25.4 ± 1.5
BUN, mg/dL	20.3 ± 1.6	21.3 ± 1.3	21.6 ± 2.2	22.2 ± 2.5	22.9 ± 2.6	30.9 ± 5.6a	21.8 ± 2.3	21.6 ± 1.8	25.8 ± 2.8b
Crea, mg/dL	0.53 ± 0.14	0.54 ± 0.13	0.56 ± 0.09	0.43 ± 0.22	0.47 ± 0.09	0.71 ± 0.18a	0.43 ± 0.19	0.36 ± 0.12	0.55 ± 0.11b
HCt, %PCV	48.8 ± 3.2	49.3 ± 3.8	49.0 ± 3.3	46.9 ± 3.1	45.7 ± 2.4	51.7 ± 6.2	46.6 ± 4.2	43.7 ± 1.8	52.5 ± 1.9
Hb, g/dL	16.2 ± 1.7	16.9 ± 1.2	16.7 ± 1.1	16.4 ± 0.9	15.5 ± 0.8	17.5 ± 2.2	15.7 ± 0.9	14.5 ± 0.4	17.9 ± 0.6
AnGap	17.5 ± 3.9	17.8 ± 3.1	17.8 ± 3.3	16.3 ± 2.4	15.9 ± 2.2	17.6 ± 2.5	13.3 ± 1.9	12.7 ± 1.8	18.6 ± 1.4

Values are mean ± SD. Cardiac spinal afferent reflex ablation by resiniferatoxin prevents the renal dysfunction measured by blood creatinine, BUN, and potassium in rats with chronic heart failure.

AnGap = anion gap; BUN = blood urea nitrogen; Cl = chloride; Crea = creatinine; Hb = hemoglobin; HCt = hematocrit; iCa = ionized calcium; K = potassium; Na = sodium; TCO₂ = total carbon dioxide.

^aP < 0.05 vs 6-8 wk or 12-14 wk.

^bP < 0.05 vs CHF+Vehicle.