Central Illustration.

Measured Versus Estimated Peak Oxygen Consumption in Post-Treatment Primary Breast Cancer

(Top) Directly measured peak oxygen consumption (Vo₂peak) using a CPET (n = 380) and estimated Vo₂peak using established equations (American College of Sports Medicine [ACSM], Fitness Registry and the Importance of Exercise National Database [FRIEND], and heart failure [HF]-FRIEND) and oncology-specific equations developed from patient and exercise test characteristics were compared in women previously treated for breast cancer. (Bottom) ACSM and FRIEND equations overestimated Vo₂peak and had poor accuracy compared with cardiopulmonary exercise test (CPET)-measured Vo₂peak. HF-FRIEND and oncology-specific equations could be applied to estimate Vo₂peak in settings where the CPET is not available. Onc_peak = oncology peak; Onc_sub = oncology submaximal.