Table 4.

Changes in biomarker levels in the study groups

Variables	Group A (Atorvastatin)	Group B (Aspirin)	Group C (Both)	Group D (None)	P Value
CRP (mg/dl)
Pre	1.05 (0.25–3.65)	1.36 (0.20–6.72)	0.95 (0.18–4.74)	1.05 (0.23–4.48)
Post	0.59 (0.13–1.60)	0.60 (0.16–1.77)	0.49 (0.09–1.59)	0.61 (0.13–2.34)
Percentage (%) change
Per protocol	− 49.71 (− 81.98–3.50)	− 53.81 (− 84.73–9.09)	− 54.77 (− 82.76–29.22)	− 44.73 (− 81.22–14.09)	0.89
As per treatment received	− 51.56 (− 82.14–4.85)	− 54.84 (− 84.73–8.10)	− 55.41 (− 83.59–28.60)	− 62.59 (− 84.77–4.12)	0.86
IL-6 (pg/mL)
Pre	4.95 (1.35–17.45)	5 (1.3–20.6)	6.15 (1.2–27.0)	4.9 (1.2–13)
Post	2.7 (0.75–8.7)	2.8 (0.8–9.6)	2.25 (0.7–6.4)	3.3 (1.2–10.9)
Percentage (%) change
Per protocol	− 27.83 (− 78.91–98.21)	− 40.42 (− 79.86–71.42)	− 53.46 (− 84.29–23.21)	0 (− 66.79–142.46)	0.007
As per treatment received	− 27.83 (− 79.71–98.21)	− 40.42 (− 79.86–71.42)	− 51.54 (− 83.08–23.21)	− 16.66 (− 72–120)	0.08
Trop I (ng/mL)
Pre	0.006 (0.001–0.007)	0.005 (0.001–0.01)	0.006 (0.001–0.01)	0.005 (0.001–0.007)
Post	0.004 (0.001–0.006)	0.005 (0.001–0.008)	0.004 (0.001–0.006)	0.003 (0.001–0.006)
Percentage (%) change
Per protocol	− 11.98 (− 83.33–40)	0 (− 83.33–50)	− 33.33 (− 83.33–0)	0 (− 83.33–50)	0.55
As per treatment received	− 16.66 (− 83.33–40)	0 (− 83.33–40)	− 34.52 (− 83.33–0)	− 24.03 (− 83.33–50)	0.64

All values are Median (p25-p75); Bold P values are significant

CRP C-reactive protein, IL-6 interleukin 6, Trop I troponin I, IU International Unit, L litre, mg milligram, mL millilitre, pg picogram, ng nanogram

Local lab ranges: CRP ≤ 0.06 mg/dl, IL6 = 0–4.4 pg/ml, Ferritin = 22–322 ng/ml, D-dimer ≤ 500 ng/ml, CPK = 32–294 IU/L and Troponin I ≤ 0.04 ng/ml