Fig. 5.

MMP-2/-9 double knockout does not worsen lung function in experimental lung fibrosis in mice. WT and MMP-2/-9 dKO mice were treated with empty control vector (AdCL) or AdTGF-β1 for 21 days and were then subjected to invasive lung function testing. A, B Inspiratory capacity (IC; A) and static compliance (Cst, B) in the lungs of AdCL treated (white dots) or AdTGF-β1 (black dots) treated WT or MMP-2/-9 dKO mice, as indicated. C Tissue elastance (H) analysed on day 21 after AdCL (blue triangle) or AdTGF-β1 (white triangle) treatment of WT mice, and AdCL (green squares) or AdTGF-β1 (red squares) treatment of MMP-2/-9 dKO mice. *indicates p < 0.05, **p < 0.01 of AdTGF-β1 relative to AdCL exposed WT mice. Data are shown as scatter plots with median values indicated as horizontal lines (A, B) or mean ± SD (C) of n = 5–8 mice per time point and treatment group and are representative of two independent experiments. *p < 0.05, **p < 0.01 (A, B) (Mann–Whitney U test), or two-way ANOVA (C)