Figure 7.

TBI reduces both quantal size and frequency of SOM-mediated inhibition. A, Example optogenetically evoked qIPSCs elicited with strontium replacing calcium in the aCSF, recorded from pyramidal neurons in sham (gray) and TBI (red) conditions after 10 ms light stimulation of SOM+ neurons. The yellow line denotes window of analysis after stimulation. B, qIPSC frequency (*p = 0.0159; unpaired t test). C, qIPSC amplitude (**p = 0.0086; Welch's t test). Each neuron is represented with a symbol, and solid lines indicate mean ± SEM [n = 11 sham and 12 TBI neurons from 3 (sham) and 3 (TBI) animals/group].